Alabama Rot (CRGV) is a poorly understood and frequently fatal condition in dogs, causing severe skin lesions and acute kidney injury. Although the disease has been recognised in the UK since 2012, the underlying cause and mechanisms remain unclear — meaning there is currently no treatment and no cure.
This project seeks to define the causes and progression of the disease, laying the foundation for improved diagnosis and future treatment strategies.
The team behind the science
A specialist research team at the University of Bristol will lead the work, including a full-time PhD student dedicated to studying Alabama Rot. They will be supported by experts in pathology, infectious disease and veterinary science.
Dr Tristan Cogan, Senior Lecturer in Infectious Disease
Dr Natalie Finch, Veterinary Nephrology Specialist
Dr Helen Howshall, Veterinary Science Researcher
Working in collaboration with Bristol Renal & Wolfson Bioimaging Facility, the project will utilise the UK’s only CRGV tissue biobank, established and maintained at Bristol.
What the project entails
Elucidate disease triggers and mechanisms This research will investigate the underlying triggers and pathophysiological mechanisms of Alabama Rot (CRGV), examining structural and functional changes in organs and blood vessels to better understand how the disease develops and progresses.
Establish clearer diagnostic criteria
Currently, diagnosis often occurs at an advanced stage of disease. A key objective of this project is to define robust diagnostic criteria that support earlier recognition and more consistent diagnosis in clinical practice.
Inform the development of future treatments
By advancing understanding of disease mechanisms, this research aims to provide a scientific foundation for the development of effective therapeutic strategies and, ultimately, preventative approaches.
Why donor support matters
There is no cure.
There is no known cause.
There is no progress without research.
Veterinary science needs answers — and this project exists to find them. Donor support funds the research team, lab work and analysis required to enable this study to progress. With funding, the project can begin in October and will run until 2029.
Every donation brings us one step closer to understanding, treating and preventing this devastating disease. Your generosity could help discover what causes Alabama Rot — and ultimately help protect dogs everywhere.
